If a nursing mother can be an extremely-quick metabolizer of codeine, it could lead into a morphine overdose inside the nursing infant and cause incredibly really serious side effects. For nursing mothers having this medicine:
Normal usage of co-dydramol during pregnancy may induce drug dependence inside the foetus, bringing about withdrawal symptoms within the neonate.
This medicine is an opioid, which can result in addiction.You may get withdrawal symptoms if you quit using it all of a sudden.
When prescribing opioids with serotonergic medicines, consider the risk of a drug-drug interaction leading to serotonin syndrome.
Sự giảm nồng độ dihydrocodeine trong huyết tương sau tiêm tĩnh mạch được mô tả theo cấp số nhân, với sự giảm trong 2 giờ đầu sau khi sử dụng thuốc và sau đó tiếp tục giảm theo cấp số nhân. Độ thanh thải không phụ thuộc vào liều lượng.
4.six Fertility, pregnancy and lactation Pregnancy There are no or limited volume of information from the use of dihydrocodeine in Expecting Ladies. Common use during pregnancy may well cause drug dependence from the foetus, leading to withdrawal symptoms from the neonate. Dihydrocodeine ought to only be made use of during pregnancy and labour if considered crucial because of the chance of neonatal respiratory depression.
Central Anxious Method The principal actions of therapeutic worth of dihydrocodeine are analgesia and an antitussive influence (depression on the cough reflex by immediate impact on the cough centre during the medulla). Antitussive effects may possibly come about with doses reduced than All those generally necessary for analgesia.
If you are pregnant or breast-feeding, think you could be pregnant, or are here planning to have a newborn, ask your medical professional or pharmacist for guidance in advance of using this medicine.
Drug withdrawal syndrome Just before setting up treatment with any opioids, a dialogue needs to be held with patients to put in place a withdrawal strategy for ending treatment with dihydrocodeine.
Warning ought to be taken when paracetamol is made use of concomitantly with flucloxacillin as concurrent intake has been involved with high anion gap metabolic acidosis, specifically in patients with risks elements (see section 4.four).
Dihydrocodeine is changed into a strong opioid drug (dihydromorphine) in One's body. In a number of people, this variation comes about quicker and much more completely than regular, which raises the danger of really severe side effects.
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AA. Characterization with the human cytochrome P450 enzymes associated with the metabolism of dihydrocodeine.
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